Premier League leaders Manchester City will travel to Everton in the FA Cup quarter-finals.
Pep Guardiola's City, the competition favourites, reached the last eight with a 3-1 win at Swansea on Wednesday while the Toffees went through with a memorable 5-4 defeat of Tottenham after extra time.
City, who have won their last 15 games in all competitions in a record-breaking run for an English top-flight side, are also due to face the Merseysiders in a rearranged Premier League game next week.
It is a game in which there could be some needle after Guardiola criticised Everton's response to the postponing of their scheduled match in December when five City players tested positive for Covid-19.
In another mouthwatering quarter-final tie, Manchester United, currently second in the Premier League, were handed a trip to third-placed Leicester.
The two sides fought out a 2-2 draw when they last met on Boxing Day.
Southampton's reward for their victory over Wolves on Thursday was an away trip along the south coast to Championship side Bournemouth.
The final tie saw Chelsea, the winners of Thursday's late game at Barnsley, drawn at home to Sheffield United.
The ties are scheduled to take place over the weekend of 20-21 March.
FA Cup sixth-round draw
Everton vs Manchester City
Leicester vs Manchester United
Bournemouth vs Southampton
Chelsea vs Sheffield United
