A student was stabbed to death while walking home from a party in a "random attack", according to reports.
The unnamed Manchester Metropolitan University student, 19, was found with stab wounds in the early hours of Wednesday morning.
Police raced to the scene where the victim was given CPR, but sadly died.
The student had been walking home from a party when he was attacked by someone he didn't know, the Manchester Evening News reports.
Councillors have spoken of their outrage and they repeated their calls for the 'awful and unnecessary death' of young people to be stopped in the city.
Greater Manchester Police say they have now launched a murder investigation after the young man was "robbed" of his life, with more officers expected to be patrolling the area and reassuring the student community over the coming days.
Following the incident, Coun Jade Doswell, Manchester Council member for Fallowfield, shared the grief felt by those in her ward.
She said she is working with charities to raise knife crime awareness, and said: "This news is absolutely heartbreaking, and my sincere thoughts are with the victim's family, I can't imagine what they are going through.
"I'm absolutely devastated that another young life has been taken on the streets of Fallowfield. It has absolutely got to stop.
"Alongside the work, I'm doing with Fallowfield-based Charity Merosworld, around preventative youth work, bleed cabinet distribution and education on knife crime awareness, we will be speaking to GMP and the Community Safety Team once we have more information on this incident, about what action we should be taking to get knives off the streets of Fallowfield and stop the awful and unnecessary death of young people here."
And Ali-Raza Ilyas, a fellow local councillor publicly extended thoughts to the victim's family on Twitter on Wednesday, writing: "Really sad, and tragic news this morning.
"A police investigation is still underway - but yet again, it appears to be another senseless stabbing. My thoughts are with the family today."
Detective Superintendent Neil Jones, of Greater Manchester Police South Manchester Division, added: "This was a terrible crime which has robbed a young man of his life and my thoughts are with his family at this devastating time.
"I understand it will cause distress and concern to many in Fallowfield and across Manchester more widely, including our large student community."
"The investigation is in its early stages, but I can assure you that our officers are working round the clock and carrying out extensive enquiries to establish the full circumstances surrounding this incident.
"We are actively pursuing leads and will relentlessly pursue the offender to ensure they are brought to justice."
An MMU spokesperson said: “We can confirm that Greater Manchester Police has informed us that one of our students died in an incident in Fallowfield in the early hours of Wednesday morning.
"Our thoughts are with their family and friends at this difficult time. We will be contacting them to offer our help and support. This will be a terrible shock to our whole community and we will be arranging for professionally trained counselling staff to support any students and staff who are affected by the incident. We cannot offer further comment at this time.”
Anyone with any information should contact GMP by calling 101 quoting log 240 of 26/10/22. Alternatively, you can report information via www.gmp.police.uk
Members of the public can upload any information including photos, videos and CCTV via our Major Incident Public Portal following this link: https://mipp.police.uk/operation/06GMP22E12-PO1 Information can also be shared anonymously via the independent charity - Crimestoppers - on 0800 555 111.