Sevilla are the continent's Europa League specialists.
The Spanish side won three Consecutive Europa League finals in 2014, 2015 and 2016 but saw that domination ended by United's victory in 2017.
Bookies thepools.com make Ole Gunnar Solakjaer's men 6/4 favourites to progress on Sunday night.
Despite their Europea League pedigree Sevilla are 2/1 , possibly based on how hard they had to work to see off a world weary Wolves side on Tuesday.
Sevilla had 76 per cent of the ball and won 14 corners to nil against Wolves, but had to wait until almost the final minute to make the break through.
And that pattern seems tailor-made for United's pacy counter attacking style.
The draw half-time, United full-time is a very appealing 17/4 . United have not conceded a first-half goal in any of their last four European games and Sevilla's last six Europa League matches have all yielded Under 2.5 goals.
Also of interest is the stat that Sevilla and Man Utd are the top two clubs in the Europa League for Corners Won this season.
Sevilla top that unofficial table with an average of 7.4 corners per game. United are second with an average of 5.64.
In the Premier League this season, United won the Most Corners in 58 per cent of games. In La Liga in Spain, Sevilla were the No.1 team for that bet, winning the Most Corners in 66 per cent of games.
Since the restart in June, United have won the Most Corners in eight of 13 matches in all comps. Sevilla have a matching record.
So look out for high corner bets.
Top Tip
Draw half-time United full-time 17/4. Bet here:
