Manchester United boss Ole Gunnar Solskjaer has made five changes to the side which beat Partizan on Thursday.
Victor Lindelof returns for United, with Daniel James, Andreas Pereira, David De Gea and Brandon Williams also starting.
Sergio Romero, Marcos Rojo, Ashley Young, Mason Greenwood and Juan Mata make way.
Man Utd: de Gea, Wan Bissaka, Lindelof, Maguire, Williams, McTominay, Fred, James, Andreas Pereira, Rashford, Martial.
Subs: Jones, Mata, Lingard, Rojo, Romero, Greenwood, Garner.
Brighton: Ryan, Montoya, Dunk, Duffy, Burn, Propper, Stephens, Alzate, Trossard, Maupay, Connolly.
Subs: Gross, Balogun, Murray, Mooy, March, Schelotto, Button.