Ole Gunnar Solskjaer and Unai Emery both have some big calls to make as Manchester United host Arsenal in tonight's huge Premier League clash.
Marcus Rashford has been ruled out with a groin injury, while Anthony Martial suffered a setback in his recovery from a thigh problem.
That could mean Mason Greenwood earning his first Premier League start of the season: the 17-year-old has scored in successive games against Astana and Rochdale and is now pressing to be included.
Solskjaer is still hopeful he can include Martial in his squad, while Paul Pogba is also an injury doubt for United in what already looks like a vital match for the under-pressure boss.
Luke Shaw could be back from a hamstring strain.
United go into the game 13 points adrift of leaders Liverpool, albeit with a game in hand, and the Red Devils can ill-afford a slip-up against a direct top-four rival.
As for Arsenal, Emery has several defensive options at his disposal: Hector Bellerin, Rob Holding and Kieran Tierney all made their long-awaited returns from injury in Tuesday’s comfortable EFL Cup win over Nottingham Forest.
The Spaniard hinted Monday may come too soon for Bellerin to play 90 minutes at such a difficult venue and if taken at his word, he must choose whether to persist with Calum Chambers - who impressed against Forest - or restore Ainsley Maitland-Niles at right-back.
Emery has favoured a midfield diamond in their last two League away games – a 3-1 defeat at Liverpool and a 2-2 draw at Watford – and may do so again given the Gunners’ poor record at Old Trafford, where they have not won in the League since 2006.
A three-man defence or a more conventional 4-2-3-1 are possible alternatives but either way Pierre-Emerick Aubameyang will spearhead the attack, looking to extend his run of six goals in six League games.
Man Utd vs Arsenal predicted lineups
Man Utd (4-2-3-1): De Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; McTominay, Pogba; Pereira, Lingard, James; Greenwood
Arsenal (4-1-2-1-2): Leno, Chambers, Sokratis, David Luiz, Tierney; Xhaka, Guendouzi, Willock; Cebellos; Aubameyang, Pepe
Team news accurate as of Monday, September 30. 2019.