Ole Gunnar Solskjaer has suggested Alexis Sanchez and Nemanja Matic will be involved against Everton on Sunday.
Sanchez made his return from a knee problem against Barcelona in midweek while Matic was back on the substitutes bench.
But Solskjaer confirmed both will feature at Goodison Park in what will be a huge clash in his side's fight to finish in the top four.
"Nemanja and Alexis had a good session yesterday as well, so they will probably be involved," Solskjaer said in Friday's press conference.
The clash will come too soon for Ander Herrera although he is progressing well while there is also good news on Eric Bailly.
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"The squad is looking good and getting better and better, I have to say," the United boss added.
"Ander is back in training - he’s been working really hard. Eric will be back in training over the weekend, Antonio (Valencia) we’re not sure about yet."
United welcome Luke Shaw back from suspension after he missed the defeat at the Nou Camp.
Romelu Lukaku could also come back into the starting line-up against his former club.
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Meanwhile, Solskjaer has sent out a warning to his under-performing players and revealed he has held talks with members of his squad, including Anthony Martial.
“Most of them have really impressed in their attitude and some need to get a reality check of where they're at,” said Solskjaer.
“But most of these know they can improve if they keep working as they do.
“I've spoken to individuals and they know. Anthony is one I've spoken to, about what we expect from them.
“Anthony's got a massive talent, he's got a new contract and knows we believe in him, so he just has to keep working.
“I think anyone that plays for Manchester United has to deliver to stay in the squad and stay in the team.
Man Utd squad
De Gea, Romero, Grant, Dalot, Darmian, Young, Jones, Shaw, Lindelof, Rojo, Smalling, Fred, Matic, McTominay, Pereira, Pogba, Lingard, Mata, Martial, Sanchez, Lukaku, Rashford.
