Cristiano Ronaldo and Marcus Rashford are set to team up in attack for Manchester United's game with Newcastle United.
The Red Devils travel to the north east looking to keep up their winning run against the relegation threatened Magpies.
Ralf Rangnick has won both of his Premier League games so far, both by a narrow 1-0 score line.
He has also implemented a 4-2-2-2 formation, that again is expected to be his go to at St James' Park.
Ronaldo scored United's winner from the spot last time out at Norwich City and it was Rashford alongside him at Carrow Road.
Rangnick is set to stick with an unchanged front six which means Jadon Sancho continues to get more minutes alongside Bruno Fernandes.
Have Your Say! Where will Man Utd finish in the Premier League? Tell us in the comments here.
Man Utd 2021 review: Promise failed to deliver as Ronaldo return led to inevitable exit
Read more: Rangnick narrows down Man Utd wishlist as he edges towards first signing
Paul Pogba remains the only member of the squad unavailable through injury.
Fred and Scott McTominay are expected to sit in front of the back four once again with the United boss weighing up new signings in that area come the New Year.
Diogo Dalot could continue his renaissance on the right of defence and again get the nod ahead of Aaron Wan-Bissaka.
Luke Shaw could return having missed the last league outing at Norwich. Victor Lindelof is expected to partner Harry Maguire at the heart of defence.
United have been among the teams to be hit by Covid in recent weeks, which forced some of their games to be postponed.
Rangnick though is confident that his side will be prepared for the clash in the north east.
He said: "Well, as far as I could see in training today, they are all in good shape. They did their homework; they all have their schedules to train at home and they stuck to that schedule and to that programme.
"From what I saw today in training, I can say most of them - if not all of them - might be available, and of course, I would have to take some difficult decisions, who will be in the squad, who will be in the starting XI."
United comfortably won this fixture last term and will again be favourites to pick up the three points.
Arsenal in fourth are currently five points clear of the Red Devils, albeit they have played two games more.
West Ham United also sit above United, but they too have played more games.
Man Utd predicted lineup: (4-2-2-2) De Gea; Dalot, Lindelof, Maguire, Shaw; Fred, McTominay; Fernandes, Sancho; Ronaldo, Rashford
