Bruno Fernandes is expected to return to the Manchester United starting line-up for their clash with Sheffield United.
The Portuguese star came off the bench to fire home the winner in Sunday's FA Cup tie with Liverpool.
Ole Gunnar Solskjaer opted to rest his star man before calling on him with 25 minutes to go at Old Trafford.
The playmaker is poised to be one of several changes with Eric Bailly coming in at the heart of defence.
The Ivorian has shared his role with Victor Lindelof over the past month or so with the Swede partnering Harry Maguire on Sunday.
Edinson Cavani is set to keep his place at the point of the attack meaning Anthony Martial misses out.
There were injury fears around Marcus Rashford, who scored on Sunday, but a scan revealed no serious damage and he is set to start.
“Marcus is available, yeah," said Solskjaer. “He trained this morning. I think he tweaked his knee a little bit but should be fine.
“We are looking strong, which is a good place to be in.”
Sunday's other goal scorer Mason Greenwood is expected to complete the attacking quartet.
Paul Pogba and Fred are both set to start at the base of midfield against the Blades, who remain rooted to the bottom of the table.
Dean Henderson, who spent two years at Bramall Lane, is likely to drop to the bench with David de Gea returning.
United ran out 3-2 winners when these two met last month in Yorkshire.
Rashford got two of their three that night and another win will take them back above rivals Manchester City at the top, albeit they will have played a game more.
Man Utd predicted line-up: De Gea, Wan-Bissaka, Bailly, Maguire, Shaw, Fred, Pogba, Greenwood, Fernandes, Rashford, Cavani
