Ole Gunnar Solskjaer is set to switch things around against West Ham , with the Manchester United boss likely to make three changes to his team who were beaten by Barcelona .
United host their Premier League rivals on Saturday evening looking to bounce back from their midweek Champions League defeat at Old Trafford.
Ander Herrera and Nemanja Matic remain out for the Red Devils boss, although the latter is attempting to come back from illness.
Luke Shaw and Ashley Young are suspended but Matteo Darmian is available, while Marcos Rojo could well come in at left-back for his first start under Solskjaer.
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Eric Bailly and Antonio Valencia also look set to miss out, so too Alexis Sanchez as he returns from an ankle injury. "He is training with us," Solskjaer said of the Chile forward.
"He's trained twice, trained today, I'm not sure if he's going to be available.
“He's injury free but not sure 100 per cent for tomorrow, maybe more likely for Barcelona game. Let's see."
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Solskjaer is expected to revert a diamond 4-4-2 formation, meaning Diogo Dalot will switch to right-back and Rojo comes in to play down the left defensive flank.
Anthony Martial, meanwhile, is expected to start up top in place of the rested Marcus Rashford while Jesse Lingard looks set to replace Shaw.
Predicted Man Utd XI: De Gea; Dalot, Smalling, Lindelof, Rojo; McTominay, Fred, Pogba, Lingard; Lukaku, Martial.
