Alexis Sanchez and Victor Lindelof are Manchester United two major absentees against Southampton, with both facing lengthy lay-offs.
Sanchez tore his hamstring in his right leg during training on Thursday, which Jose Mourinho fears will keep the Chilean out for six weeks.
Lindelof, too, will miss much of December, following a groin injury sustained against Crystal Palace last week.
Luke Shaw is available again after serving a suspension against Palace, while Diogo Dalot is set to start at right back.
Ahead of Saturday’s match at St Mary’s Mourinho told MUTV: “Players must be ready and in this case some are going away to the medical room and others are coming back. For example, this weekend will be the first call for Dalot. He’s ready now.
“He had an important injury and then surgery, and then a second injury with the national team when he was already playing against Young Boys and Derby County.
“When he was almost there, he was injured for the national team but now he’s had two weeks of training and we think he’s ready now.”
Man Utd injury, suspension list | Team news vs Southampton
| Player | Condition |
| Victor Lindelof | Groin injury (out) |
| Alexis Sanchez | Hamstring injury (out) |
| Matteo Darmian | Missed training (doubt) |
| Marcos Rojo | Missed training (doubt) |
