A man was taken to hospital with a nose injury after a fight at celeb hotspot Chinawhite.
The incident happened in the early hours of last Sunday.
An eyewitness told the Manchester Evening News the victim was hit with a bottle, adding: "It was chaos inside."
It is believed a Premier League footballer was present at the time of the incident, although there is no suggestion that he was involved in the violence.
Police and the ambulance service responded to the scene on Deansgate at around 3.45am.
A spokesperson for the ambulance service said a man in his early 40s was taken to hospital with a nose injury.
The injury was not thought to be serious.
Police said they attended following reports of a 'disturbance' at the venue.
It has since been established that a man was assaulted and an investigation has been launched.
No arrests have been made and officers appealed for anyone with information to come forward.
Chinawhite, an expansion of the famous London brand, opened in the former Milton Club last year.
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The original Soho venue was frequented by celebrities such as Kate Moss and Prince Harry during its heydey in the noughties.
And the Manchester offshoot has proved equally popular with some of the region's biggest names.
Manchester City held their Christmas party there last year, with players including Gabriel Jesus, Raheem Sterling and Sergio Aguero ushered in through the back door.
A GMP spokesperson said: “Shortly before 4am on Sunday 4August 2019, police officers attended a report of a disturbance at China White’s, Deansgate.
"Enquiries have since established that a man had been assaulted.
"No arrests have been made and enquiries remain ongoing.
"We would like to take this opportunity to appeal for any witnesses to come forward and contact police on 0161 856 3221”
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