A man was taken to hospital with serious injuries after being struck by a car in Stretford.
Emergency services were called to reports of a collision involving a pedestrian and a car on Chester Road.
The injured man was taken to hospital suffering from serious injuries.
A police spokesman said his injuries are not thought to be life-threatening.
Chester Road was sealed off between Edge Lane and Barton Road following the incident, which took place at 7.25pm on Wednesday night.
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Drivers were told to find alternative routes.
The road has since re-opened.
Eyewitnesses said there was a large number of police cars and road closures in the area.
Photos from the scene showed officers standing guard along the road.
There have been no reports of any arrests.
A Greater Manchester Police spokesman said: "There has been a report of a collision involving a pedestrian on Chester Road.
"A man has been taken to hospital with serious injuries, not believed to be life-threatening.
"That happened at around just before 7.25pm."
Anyone with further information or any witnesses can call GMP on 101 or Crimestoppers, anonymously, on 0800 555 111.
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