Paulo Gazzaniga was brought in for Hugo Lloris as Mauricio Pochettino made five changes to the side which progressed to the Champions League last four at Etihad Stadium on Wednesday.
Lloris dropped out of the squad altogether, while Ben Davies, Eric Dier, Davinson Sanchez and Juan Foyth were brought in to the starting XI for Saturday's League meeting.
VIncent Janssen was handed a rare spot among the siubstitutes, with Victor Wanyama dropping to the bench.
City boss Pep Guardiola three changes as Phil Foden made just his second Premier League start.
Man City vs Tottenham line-ups and team news
Man City XI: Ederson, Walker, Stones, Laporte, Zinchenko, De Bruyne, Gundogan, Foden, Bernardo Silva, Aguero, Sterling
Subs: Sane, Silva, Fernandinho, Mahrez, Otamendi, Gabriel Jesus, Muric
Tottenham Hotspur XI: Gazzaniga, Alderweireld, Sanchez, Vertonghen, Foyth, Alli, Dier, Davies, Eriksen, Son, Lucas Moura
Subs: Janssen, Rose, Wanyama, Vorm, Walker-Peters, Llorente, Skipp.
