No Sergio Aguero means it is the perfect night for a certain Brazilian striker to step up.
City sit top and need just one point to confirm qualification into the knockout stages of the Champions League when they welcome their Ukrainian opponents.
Gabriel Jesus has spoken up stepping up when called upon after Pep Guardiola confirmed Aguero will be out for a few games - including the Manchester Derby.
The Pools caught up with Stuart Brennan ahead of tonight's European action:
Recommended bets:
Win, lose or draw?
City will make changes but should still be strong enough to beat a team who lost 6-0 at the Etihad last season. A 6-0 repeat at the Etihad is 22/1.
Who's a good bet for 1st scorer?
Phil Foden ( 8/1 ) is expected to start, and after some lively cameos this season, and his first Champions League goal, he will be eager for more
Who's on pens?
Gabriel Jesus ( 11/5 ) has missed his last two, but there is no indication he won't continue, with Aguero injured.
Will City keep a clean sheet?
Not always convincing defensively in the Premier League, but they should be able to shut out a tame Shakhtar attack ( 7/10 ).
