Pep Guardiola’s side go into their first match after the international break knowing a win is required to keep up with the pace being set the Chelsea.
City currently trail the Blues by six points, but face an Everton team that they have beaten in each of the last eight matches between the sides in all competitions.
Kevin De Bruyne tested positive for Covid-19 while on international duty, so will not available while he isolates, while Jack Grealish and Phil Foden both picked up knocks playing for England and late decisions will be made on their fitness.
City lost their last home match in the Premier League, to Crystal Palace, and will be looking to find their top form again ahead of hosting PSG in midweek.
Everton sit 11th in the table going into the match, but know victory at the Etihad would lift them up to seventh and just five points off the top four.