Manchester City now enjoy a six-point cushion over nearest title rivals Liverpool following the Reds potentially costly slip-up away at Leicester City on Tuesday evening.
The third horse in what looks set to be a thrilling title race comes in the form of Chelsea, who sit level on points with Jurgen Klopp's side, both boasting 41 points on the board after 19 games played.
As the entire division begin to make their way out of what was a truly hectic festive fixture pile-up, it is Pep Guardiola's City who can be happiest with their display - faultless throughout, winning their last nine league games.
The reigning Premier League champions last tasted league defeat back in late October after Patrick Vieira's Crystal Palace sprung a surprise victory at the Etihad.
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While Man City and Chelsea have one more league tie to play in 2021, Liverpool are not called into league action until the turn of the year now, the Reds playing their final football of this year in the most recent match-week.
With that being said, Mirror Football has taken a look at the next six fixtures for each side - taking us into mid-February as all three aim to sit pretty at the top come the end of the campaign.
Manchester City
Guardiola's men are looking increasingly likely to break their own record of consecutive Premier League victories of 18, a feat they share with Klopp's Liverpool.
City appear to be in unstoppable form, putting the early season fears of failing to sign a striker in the summer to bed after notching a frankly ludicrous 17 goals in their least three league outings.
Up next for City is a tricky away tie at newly-promoted Brentford, who have already proven they can make life difficult for the division's big boys.
The Bees toppled one big six-outfit in Arsenal on the opening day of the season, but have also proved to be a stern test for City's main title rivals in Liverpool and Chelsea.
While the Blues did make the short trip back to west London with all three points, their victory came in the form of a gritty 1-0 win that required Edouard Mendy to be at his best.
Liverpool were not so lucky, forced to share the spoils with Thomas Frank's side after a thrilling 3-3 draw.
January looks set to throw up some early tests for City, the first coming on New Year's Day away at Arsenal, led by former City assistant Mikel Arteta.
After a break from league action to fulfil FA Cup duties, City welcome Chelsea to the Etihad on January 15 in what could prove to be a pivotal tie in the race for the title.
Things should get a tad easier, at least on paper, after that meeting as City then travel to Southampton and relegation zone-dwellers Norwich either side of a second clash with Brentford.
Liverpool
The Reds see their January dominated by domestic cup action given they, unlike City, remain in the Carabao Cup as the competition's final four face-off.
As a result, the next six league fixtures takes them up until February 19, with some crucial clashes between now and then.
The first is arguably the most important as Liverpool aim to dish out what would be Chelsea's second home defeat of the season, Klopp's men looking for their second successive victory at Stamford Bridge after last year's 2-0 win.
The fixture presents Liverpool with the chance to put some breathing room between the Blues and themselves after defeat to Leicester ensured they will go into 2022 level on points.
After a high-stakes meeting with Chelsea comes a home tie with Brentford as Liverpool look to avenge the three points that were stolen from them late on at the Brentford Community Stadium back in September.
An away clash with Crystal Palace comes a week later, Liverpool's last game for over a fortnight before they return to action at home to Leicester on February 10.
The Reds are then forced to play three games in six days, two of which come in the league in the form of a trip to Sean Dyche's Burnley before welcoming Dean Smith's Norwich to Anfield either side of the first leg of the Champions League round of 16 tie with Inter Milan.
Liverpool are set to be without talismanic forwards Mohamed Salah and Sadio Mane for much of this period due to the Africa Cup of Nations.
Chelsea
After such a glorious end to last season with Champions League glory, Thomas Tuchel's Chelsea started this term in bright enough fashion, though their form has since waned in recent weeks.
The festive period, though hardly a disaster, could have gone better for the Blues, who won just three of their six league fixtures so far in December.
The Blues have one more to go this month, welcoming Brighton & Hove Albion to west London on Wednesday evening for the pair's first meeting of the season.
As mentioned, their first clash of the new year sees them take on Liverpool at Stamford Bridge in a game that will have a huge impact on all three sides in the hunt for the title.
Just under two weeks pass before their next league fixture, away at the Etihad aiming to avenge the 1-0 defeat inflicted upon them by Guardiola's men earlier this season.
Following that, a reunion with former manager Antonio Conte lie in wait as the Italian prepares to take his Spurs side to his old stomping ground.
It was hardly a harmonious split between Conte and Chelsea, the ex-Blues boss can expect some jeers upon his return, especially given he now leads one of Chelsea's London rivals.
An away game at Crystal Palace comes three weeks later after Chelsea spend the first week of February gearing up for the Club World Cup semi-final.
Former coach Brendan Rodgers also returns to Chelsea on February 26 when Leicester come to town, by which time the Blues will hope to be at least still within touching distance of table-toppers Man City.
