A man and a woman were trapped in a car following a collision near to Daisy Nook Country Park.
Emergency crews were called to a collision involving two vehicles on Stannybrook Road, in Failsworth, at 11.35am on Monday morning.
Firefighters used specialist equipment to release a man and woman trapped inside one car.
The ambulance service said a man, aged in his late 40s, was taken to hospital with serious injuries.
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An ambulance and a rapid response vehicle remains at the scene.
A section of Stannybrook Road has been shut.
The North West Ambulance Service said in a statement: "We were called at 11.26am. We have attended with two ambulances and a rapid response vehicle.
"It is still ongoing. We have got a man in his late 40s with serious injuries.
"He has been taken to hospital.
"We are still on the scene with an ambulance and a rapid response vehicle."
A spokesman for Greater Manchester Fire and Rescue Service said: "We were called at 11.35am this morning to Stannybrook Road in Failsworth, near to the garden centre.
"It is a road traffic collision involving two vehicles.
"Crews are currently in attendance.
"Two people are trapped, but conscious and breathing - a man and a woman."
