A Boeing 737 passenger plane lost contact and disappeared shortly after take off.
Indonesian officials say the Sriwijaya Air jet lost contact with air traffic controllers after taking off from Jakarta for Pontianak in West Kalimantan province this morning.
A search and rescue operation is now under way.
There were 62 people on board - including 56 passengers and six crew.
The Sriwijaya Air took off from Jakarta at about 1.56pm and lost contact with the control tower at 2.40pm.
The Indonesian Transport Ministry spokesperson, Adita Irawati, confirmed that there had been a loss of contact with the Sriwijaya Air aircraft.
"The missing plane is currently under investigation and under co-ordination with the National Search and Rescue Agency and the National Transportation Safety Committee," Irawati said in a statement.
A statement released by the airline said the plane was on an estimated 90-minute flight from Jakarta to Pontianak, the capital of West Kalimantan province on Indonesia’s Borneo island.
Flight monitoring website Flightradar24 said: "Sriwijaya Air flight #SJ182 lost more than 10,000 feet of altitude in less than one minute, about 4 minutes after departure from Jakarta."
Sriwijaya Air has said it is still gathering more detailed information regarding the flight before it can make any statement.
