Drivers are facing 90 minutes delays on the M62 due to a multi-vehicle crash.
Two lanes have been shut on the westbound carriageway at junction 22 near Saddleworth.
Traffic police are warning of seven-mile tailbacks and 90 minute delays to people's journeys.
Drivers are being urged to consider alternative routes while the emergency services attend the crash.
It is unclear whether anyone has been hurt.
Highways England, in a tweet, said: "Please be aware there are SEVERE delays on approach to this incident.
"Average journey times are now well over an hour and a half above normal for this time of day, with over 7.5 miles of congestion.
"Consider alternative routes if you can this evening."
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