The M25 has been closed to traffic flowing anti-clockwise in Surrey after a collision involving an ambulance, police say.
Surrey Police said in a statement the motorway was closed between junctions 8 and 9 after the incident which occurred at around 3.30am, and would remain closed for at least three hours, possibly stretching into the rush hour.
The collision involved an ambulance, a car and an HGV, police said.
The driver of the car has been taken to hospital with serious leg injuries, while the occupants of the other vehicles were unhurt.
Police have asked for anyone who witnessed the collision to make contact by messaging on social media (@SurreyPolice), via chat on the Surrey Police website (surrey.police.uk) or by calling 101 quoting reference PR/20244107.
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