Marks & Spencer will join forces with Joules, Phase Eight, Hobbs and Seasalt when the high street reopens after lockdown.
The chain, which recently acquired Jaeger for £5million, said the move will help it rebrand after a year of dozens of high street casualties.
However, chief executive Steve Rowe, said Marks & Spencer outlets will not become department stores - instead following in the footsteps of rival chain Next.
"We've got no intention of turning this into a department store at all. This is about finding and partnering with adjacent brands," Rowe said.
It is understood the latest brands have been picked by M&S as they are appealing to its middle-aged female customer base.
It will be in addition to own brands, including M&S Collection, Autograph, Per Una and Blue Harbour menswear.
The collections will be stocked in stores and online and join the likes of Nobody's Child and Ghost fashion.
It also follows a trial partnership with Early Learning Centre in the run-up to Christmas boosted festive sales.
Retail analysts speculate that if Jaeger succeeds then Rowe could look to implement a more active acquisitions strategy in future.
Clive Black, analyst at Shore Capital, said: "Once we come out of lockdown and stores reopen M&S can return to profitability and strengthen the balance sheet.
"Rowe has shown with the Ocado joint venture and rights issue he does not want the company to be a victim. I think we could see more bolt-on deals in clothing, food and home."
