Mohamed Salah returns for Liverpool as they attempt to book a place in the last 16 of the Champions League at home to Atalanta.
Diogo Jota, Roberto Firmino and Andy Robertson form part of a strong substitutes' bench as Jurgen Klopp hands starts to Kostas Tsimikas and Divock Origi.
Rhys and Neco Williams both start in the Reds' back four alongside Joel Matip and Tsimikas, who makes his Champions League debut at Anfield.
James Milner moves from right-back into midfield alongside Gini Wijnaldum and Curtis Jones who both keep their place from Sunday's 3-0 win over Leicester City.
Fabinho also begins on the bench for this one as Klopp rests the versatile midfielder after his recent return from a hamstring injury.
Teenagers Jake Cain, Leighton Clarkson and Billy Koumetio are also on the bench with Liverpool aiming to go into the hat for the knockout stages for the fourth straight season under Klopp.
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Liverpool: Alisson; N Williams, R Williams, Matip, Tsimikas; Milner, Wijnaldum, Jones; Salah, Origi, Mane.
Subs: Adrian, Fabinho, Firmino, Minamino, Jota, Robertson, Cain, Clarkson, Koumetio, Kelleher.
