Thiago Alcantara makes his full Liverpool debut as they travel to Everton for the 237th Merseyside derby.
The Spain international was forced to self-isolate during the international break after testing positive for COVID-19 but comes into the Reds' midfield as they aim to respond after that 7-2 defeat to Aston Villa last time out.
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Captain Jordan Henderson also returns to the team for his first appearance since limping out against Chelsea with Fabinho completing the midfield trio.
Sadio Mane, who like Thiago, tested positive for the coronavirus this month, also comes back into the team alongside Roberto Firmino and Mohamed Salah.
Meanwhile Joel Matip replaces Joe Gomez at the centre of defence alongside Virgil van Dijk after returning to training this week as Adrian continues to deputise for the injured Alisson Becker.
Liverpool: Adrian, Alexander-Arnold, Matip, Van Dijk, Robertson, Fabinho, Henderson, Thiago, Salah, Firmino, Mane.
Subs: Kelleher, Wijnaldum, Milner, Gomez, Jones, Minamino, Jota.
