Xherdan Shaqiri makes his first Premier League start of the season as Joel Matip misses out against Manchester United.
Matip trained with his team-mates at the AXA Centre on Friday but is absent from the squad in the top-of-the-table clash at Anfield.
It means Jurgen Klopp has once again named captain Jordan Henderson at centre-back alongside fellow midfielder Fabinho with Thiago Alcantara making his Anfield debut this afternoon.
Shaqiri could start as the most advanced of a midfield three as Klopp shuffles back to something resembling a 4-2-3-1 formation in an attempt to regain top spot in the Premier League.
Up front, Sadio Mane, Roberto Firmino and Mohamed Salah take their usual places as Alex Oxlade-Chamberlain drops to the bench after the defeat to Southampton last time out in the league.
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Liverpool: Alisson, Alexander-Arnold, Henderson, Fabinho, Robertson, Thiago, Wijnaldum, Shaqiri, Salah, Mane, Firmino.
Subs: Kelleher, Milner, Oxlade-Chamberlain, Jones, Minamino, Origi, R. Williams, Phillips, N. Williams.
