Jordan Henderson will start at centre-back for the first time for Liverpool after Virgil van Dijk was ruled out of their FIFA Club World Cup semi-final.
Van Dijk is absent through illness for the game against Mexican side Monterrey in the Qatar capital Doha this evening at the Khalifa International Stadium.
Jurgen Klopp has made a total of five changes from the side that beat Watford 2-0 in the Premier League at Anfield on Saturday.
Henderson, the Reds skipper, will partner Joe Gomez at the heart of defence, while Trent Alexander-Arnold has been rested to the bench.
Monterrey vs Liverpool live match updates in FIFA Club World Cup
James Milner switches to right-back with Andy Robertson returning on the opposite side of the back line.
The midfield has been completely overhauled with Adam Lallana, Naby Keita and Alex Oxlade-Chamberlain all coming in.
And in attack, Sadio Mane and Roberto Firmino are among the substitutes, with Divock Origi starting alongside Mohamed Salah and Xherdan Shaqiri.
LIVERPOOL (4-3-3): Alisson; Milner, Gomez, Henderson, Robertson; Lallana, Keita, Oxlade-Chamberlain; Shaqiri, Salah, Origi.
Subs: Adrian, Lonergan, Firmino, Mane, Jones, Alexander-Arnold, Williams.
