Xherdan Shaqiri will be sidelined until November - as Liverpool admitted they have no idea when Joel Matip will again be available.
Shaqiri has been out since injuring his calf in training ahead of the League Cup tie at MK Dons in September.
The Switzerland international has been restricted to just four substitute appearances this season having previously injured his calf when appearing for his country in the UEFA Nations League against England.
Matip, meanwhile, continues to be hampered by the knee complaint that has ruled him out of four of the last five games.
“Shaq will only be back after the international break,” said Liverpool assistant manager
“We want to give him the time. With a calf injury it is always very high risk, especially with his calves.
“Joel’s knee is still irritated – we need to give him time. I don’t know the exact time he will need but it will really need time to heal.”
The pair will be among a host of players not considered for Wednesday's League Cup fourth round tie at home to Arsenal.
Mohamed Salah will also miss out, but Liverpool have again allayed fears of serious injury after limping off towards the end of Sunday's Premier League win over Tottenham Hotspur with the recurrence of an ankle problem.
“Mo is fine,” said Lijnders. “Towards the end of the game it is more precaution because the ankle gets more tired and he feels it a little bit more and we have to take him off. But he is fine, he is good.
“All the others are fit, hungry and ready to go.”
