Liverpool know that only a win will take them back above Manchester United in the Premier League standings on Sunday, with three points enough to guarantee them top spot post-match no matter the other results.
With a full week to prepare for the game, Jurgen Klopp and his staff have had ample time to work on their game plan, though it is very difficult to predict exactly how Ole Gunnar Solskjaer will set up.
A point would be a good result for the current league leaders, but the Norwegian might be tempted to go for more given the run of results his side are currently on.
But while it might be tough to work out exactly how Manchester United will set up, the personnel who play are easier to predict, with their strengths and weaknesses known.
"It will be interesting to see what Klopp does with players like, for example, Aaron Wan Bissaka," said Josh Williams on the Analysing Anfield podcast.
"He is a player that depending on the opposing manager, a team says 'we want Wan Bissaka to have the ball because we feel safe and he is not going to cause us any particular problems'.
"But from a Liverpool perspective, I'm thinking that Wan Bissaka could be used as some kind of trigger and the player that Liverpool push possession towards before putting him under pressure because he panics a little bit.
"There are two ways to approach both United's full-backs, but mainly Wan Bissaka.
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"They are not the strongest and they are limited anyway by the touchline, so they can be forced into mistakes. Or you can allow them the ball and know they are not particularly dangerous, so there are two ways of looking at that."
It will primarily be the task of Sadio Mane to get the better of the England man, with Andy Robertson, fresh from a near-two-week rest, able to support him.
"I don't think Wan Bissaka has turned out to be the player they thought they were buying, although I'm not really sure what they thought they were doing in terms of that recruitment," added David Hughes.
"He is quite good without the ball but is a little one-footed.
"One thing I will say is that looking at the numbers over the last few years, Solakjaer has implemented a more possession-based approach.
"David de Gea goes a lot shorter with goal kicks and there are going to be opportunities to press and force United into mistakes."
Setting traps for Manchester United to fall into could be crucial in swinging the result the way Liverpool want, especially given their recent run of form.
"Counter-pressing makes exactly the same [influence as a playmaker]," said Klopp on Sky Sports in 2016.
"No playmaker in the world can be as good as a good counter-pressing situation."
Liverpool do still counter-press, of course, but they have evolved since the early days under Klopp into a team more focussed on keeping hold of the ball rather than winning it high up the field.
And while Klopp's side are struggling to create against sides prepared to sit in and defend deep, letting the opposition have possession and pressing high up the pitch could see the counter-press become Liverpool's best playmaker once again.
Having since switched to a more possession-dominant style, a return to the old Liverpool for one game only could offer the blueprint for Anfield success.
