Kate Garraway is set to reveal all in an interview on tonight's Life Stories.
The 54-year-old broadcaster is the guest on Piers Morgan's final episode hosting the ITV chat show.
The former Good Morning Britain anchor confirmed Kate will succeed him as the face of the show in a statement issued in October.
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He tweeted : "BREAKING NEWS: I’m quitting Life Stories after 12 years and 100 shows.
"My final one will be with my fabulous friend @kategarraway and she will then present the remaining 3 planned shows of the next series as I leave ITV."
Kate presented Friday's edition of Good Morning Britain alongside her close friend Ben Shephard - and admitted she got "defensive" during the discussion with her former colleague.
She said: "He delved into my past, exes, career stuff. There are some images of me that I can't even remember looking at.
"You can see from my face that every question he asks I'm thinking 'what are you going to ask me now'. There's a defensive pose."
A topic on the agenda is set to be the story of Kate's husband Derek Draper, who fell into a coma after contracting Coronavirus in March 2020.
Derek fought off the virus, but he is still badly affected by the illness - and Kate charted his road to recovery in the award-winning documentary, Finding Derek.
Kate has been by her husband's side throughout his battle with Covid - and she opened up about the trauma of the past year in an episode of BBC's Walking With... that aired last month.
The documentary, which followed Kate through a peaceful walk in the Cotswolds, was the first time she had been away from her family since the diagnosis - and she admitted feeling "very guilty" for being apart from husband Derek and their children.
She said: "I started off feeling very guilty at the indulgence of having the space, bathed in nature, to just 'be'.
"And then as time went on as I walked & walked on my own gradually found a wonderful sense of perspective & energy renewal."
Derek is Kate's second husband - and they have been happily married since 2005.
Tonight's interview will also explore her life before Derek which included a turbulent first marriage to ITN news director, Iam Rumsey.
Kate and Ian met while working at Meridian TV before they tied the knot in 1998.
According to Mirror Online, the two separated just four years later when Kate reportedly kicked him out amid claims he'd had an affair with another TV presenter.
One of Kate's close friend told the Mirror: "She says he was cheating on her for some time and that's why she threw him out
"She had her suspicions because he was going out and staying away a lot. He always denied anything was going on but Kate still had nagging doubts - call it women's intuition - that something was not right."
"Ian kept saying everything was fine, but she says the affair became common knowledge and eventually she got to hear the TV gossip.
"When she confronted him with it she says he eventually came clean."
Ian always denied the claims and blamed the split on Kate's long hours and 2am starts as she had just started to host GMTV as cover for Fiona Phillips, who had departed on maternity leave.
Kate drew a line under the matter when she released a brief statement to address the rumours.
She said: "It's always terribly sad when a marriage comes to an end. I'm disappointed that what's a very private matter has been brought into the public domain.
"I was dismayed by reports in the papers because they are substantially inaccurate."
The two were eventually reunited in a professional capacity when Ian was brought in as the boss of GMTV in 2010 - and Kate spoke about how the two had maintained a positive relationship after the split.
She said: "We've seen each other since, so it wasn't a case of, 'Weren't you wearing white when I last saw you?
"But before he started, I did think, 'What is this going to be like? This could be weird or really awkward.' You would, wouldn't you?"
"Seeing as we're both working together at the moment, we obviously get on and have a lot in common. I think it's good we've managed to keep a friendly relationship afterwards."
Piers Morgan's Life Stories with Kate Garraway will air tonight at 8pm on ITV and ITVHub
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