Lewis Hamilton says he is "completely overcome with rage" following the death of George Floyd, urging people not to sit in silence.
Mr Floyd, an unarmed black man, died in Minneapolis after a police officer knelt on his neck for over eight minutes.
The incident has triggered outrage, with protests in the US and beyond, while sporting figures and clubs have joined millions across the globe by remaining silent on social media as part of Blackout Tuesday in support of the Black Lives Matter movement.
And Hamilton, speaking out for the second time on the incident, said: "This past week has been so dark, I have failed to keep hold of my emotions."
"I have felt so much anger, sadness and disbelief in what my eyes have seen," added the Mercedes driver.
"I am completely overcome with rage at the sight of such blatant disregard for the lives of our people. The injustice that we are seeing our brothers and sisters face all over the world time and time again is disgusting, and MUST stop."
He added: "Those of us who black, brown or in between, see it every day and should not have to feel as though we were born guilty, don't belong or fear for our lives based on the colour of our skin," Hamilton said.
"It is only when there are riots and screams for justice that the powers that be cave in and do something, but by then it is far too late and not enough has been done."
Hamilton continued: "It took hundreds of thousands of people's complaints and buildings to burn before officials reacted and decided to arrest Derek Chauvin for murder - and that is sad," he said.
"Unfortunately, America is not the only place where racism lives and we continue to fail as humans when we cannot stand up for what is right.
"Please do not sit in silence, no matter the colour of your skin. Black Lives Matter."
F1 also made its first statement on the subject shortly after.
"We stand with you, and all people in the fight against racism," it said. "It is an evil that no sport or society is truly immune from. And it is only together we can oppose an eradicate it.
"Together we are stronger."
Additional reporting by PA
