- Labour suffered a "catastrophic" by-election defeat in Gorton and Denton, finishing third behind the victorious Green Party and Reform UK.
- The Green Party secured its first-ever parliamentary by-election win with Hannah Spencer, while the Conservatives lost their deposit, coming fourth.
- Following the loss, Labour backbenchers stated Sir Keir Starmer's departure is "a question of when, not if," with a potential timeline after the 7 May local elections.
- Angela Rayner, a potential successor, called for a change in the party's direction, while Sir Keir vowed to "keep on fighting" and criticised the Green Party's campaign.
- Concerns were raised by election observers about "concerningly high levels" of illegal family voting during the by-election.
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