The 49ers lost the heartbeat of their defense when linebacker Kwon Alexander exited Thursday’s game in the third quarter. He was ruled out with a chest injury.
San Francisco’s defense has struggled in the two games they’ve missed Alexander. He was ejected early against the Buccaneers and they had success running the ball. Arizona started racking up yards on the ground when he went out too. Azeez Al-Shaair and Dre Greenlaw are the two options to replace him.
