Knowsley has now overtaken Nottingham as the country's coronavirus hotspot.
The Merseyside local authority has the highest Covid-19 infection rate in England, according to Public Health England.
LancsLive reported that the North West as a whole now has 167,698 confirmed coronavirus cases since the start of the pandemic.
Analysis of the latest PHE figures by shows that a further 5,468 people tested positive for the virus in the last 24 hours across Lancashire, Greater Manchester, Merseyside, Cumbria and Cheshire.
This is the biggest daily increase in the second wave of the virus and comes as the UK also reported its highest daily rise in lab-confirmed Covid-19 cases since the outbreak began in March.
Figures released on Wednesday show that in Lancashire, another 1,269 cases were recorded since yesterday while Cumbria's tally also rose by 218.
There were a further 501 cases in Manchester, which will enter Tier 3 lockdown restrictions on Friday, and another 507 in Liverpool.
Cheshire's case total rose by 244 while there were also more than 200 new infections registered in Blackburn with Darwen, Bolton, Knowsley, Oldham, Rochdale, Salford and Wigan.
The North West now has nine of the top 10 highest infection rates in the county and 18 of the top 20.
The number of Covid-19 patients admitted to the region's hospital on Sunday (October 18) - the most recent daily figures available - rose from 209 to 276 compared to October 11.
There are now 2,042 in North West hospitals, up from 1,399 the week before, with 186 on ventilators.
The data below includes the total number of cases and overall infection rate for each area since the pandemic began. Many of these cases will no longer be active.
These are the number of confirmed cases of coronavirus by North West borough as of today (October 21):
There are 33,126 cases in Lancashire, 8,083 in Bolton, 4,942 in Bury, 4,949 in Cheshire East, 4,640 in Cheshire West and Chester, 5,521 in Cumbria, 2,906 in Halton, 5,256 in Knowsley, 16,014 in Liverpool, 16,421 in Manchester, 7,226 in Oldham, 6,433 in Rochdale, 6,491 in Salford, 6,647 in Sefton, 4,616 in St Helens, 5,342 in Stockport, 5,382 in Tameside, 4,791 in Trafford, 4,624 in Warrington, 7,591 in Wigan and 6,697 in Wirral.
The latest figures for the North West come as the Government announced a further 26,688 lab-confirmed cases of Covid-19 in the UK on Wednesday, taking the total number to 789,229.
See how coronavirus has affected your area by entering your postcode below
This is a jump of more than 5,000 on the 21,330 positive cases confirmed on Tuesday and the biggest since the outbreak began.
Experts have previously warned that describing the daily figure as a record could be "misleading" as it is not clear how many people were actually infected during the height of the first wave, due to a lack of community testing at the time.
A further 191 people died within 28 days of a positive test, meaning the death toll reached 44,158.
The daily number of positive cases has climbed steeply in recent weeks and has nearly doubled in the last fortnight.
The daily figure was 19,724 positive cases seven days ago (October 14) and 14,162 a week before that (October 7).
The number of patients in hospital and on ventilators is also increasing.
Last month, two of the Government's top advisers, Professor Chris Whitty and Sir Patrick Vallance, warned that cases could reach around 50,000 a day by mid-October if cases doubled every seven days.
