Colin Pitchfork is set to be released from prison after the Parole Board rejected a government challenge to block his release.
Pitchfork, now in his early 60s, was jailed for life after raping and strangling 15-year-olds Lynda Mann and Dawn Ashworth in Leicestershire in 1983 and 1986.
He became the first man convicted of murder on the basis of DNA evidence in 1988 after admitting two murders, two rapes, two indecent assaults and conspiracy to pervert the course of justice.
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Among his victims was Lynda Mann, 15, whose sister Rebecca Eastwood, from Anfield, has campaigned to keep him behind bars for the rest of his life.
Following a hearing in March, the Parole Board ruled he was "suitable for release", despite this being denied in 2016 and 2018.
But last month Justice Secretary Robert Buckland asked the board, which is independent of the Government, to re-examine the decision under the so-called reconsideration mechanism.
On Tuesday the Parole Board announced the application had been "refused".
A spokesman said in a statement: "The Parole Board has immense sympathy for the families of Dawn Ashworth and Lynda Mann and recognises the pain and anguish they have endured and continue to endure through the parole process.
"However, Parole Board panels are bound by law to assess whether a prisoner is safe to release.
"It has no power to alter the original sentence set down by the courts.
"Legislation dictates that a panel's decision must be solely focused on what risk a prisoner may pose on release and whether that risk can be managed in the community.
"As made clear in the reconsideration decision, release was supported by all of the Secretary of State's witnesses during Mr Pitchfork's review."
