Kate and Gerry McCann have thanked the British public for "being by our side".
The parents of missing Madeleine McCann were granted a £300,000 fund to continue their search for their daughter.
They said on Facebook: "Thank you for being by our side as we continue to search for Madeleine."
Madeleine was three-years-old when she was last seen on holiday with her parents in Portugal in May 2007.
Scotland Yard launched its own investigation, Operation Grange, into her disappearance in 2013 after a Portuguese inquiry failed to make any headway.
So far the investigation, dubbed Operation Grange, has cost £12m, reports Birmingham Live.
The three-year-old's disappearance triggered the most heavily reported and high-profile missing-person case in modern history.
Her whereabouts remain unknown, but the case has recently been thrown back into the spotlight by a new eight-part Netflix series.
Madeleine's parents, Kate and Gerry McCann, both doctors, have always pledged never to give up the search for their daughter.
In a statement on the 12th anniversary of her disappearance, they said: "The months and years roll by too quickly, Madeleine will be 16 this month.
"It's impossible to put into words just how that makes us feel.
"There is comfort and reassurance though in knowing that the investigation continues and many people around the world remain vigilant.
"Thank you to everyone who continues to support us and for your ongoing hope and belief."
