Covid-19 case rates are rising in all but one region of England, according to the latest weekly surveillance report from Public Health England.
The highest rate is in London, which stood at 319.3 cases per 100,000 people in the week to December 13, up from 199.9 in the previous week.
In eastern England the rate has risen from 152.9 to 249.1, while in south-east England the rate has increased from 167.6 to 238.7.
The only region that recorded a week-on-week fall was Yorkshire & the Humber, where the rate dropped slightly from 153.6 to 148.5.
This news comes as more than two-thirds of England's population will be living under Tier 3 restrictions from Saturday amid rising concern about the spread of coronavirus in the run-up to Christmas.
Health Secretary Matt Hancock placed large parts of southern and eastern England into the top tier and dashed hopes in northern regions of an easing of restrictions.
Mr Hancock told MPs he regretted having to impose the curbs but "there is a strong view right across Government that these actions are necessary".
Under Tier 3 conditions pubs and restaurants can only offer takeaway or delivery services and indoor entertainment venues are shut.
Bedfordshire, Buckinghamshire, Berkshire, Peterborough, Hertfordshire, Surrey (with the exception of Waverley), Hastings and Rother (on the Kent border of East Sussex), and Portsmouth, Gosport and Havant in Hampshire will all move into Tier 3.
Liverpool City Region has avoided the harshest coronavirus measures again - remaining in Tier 2.
The city region has done a remarkable job in fighting back against the virus, bringing infection rates in places like Liverpool and Knowsley down from around 750 cases per 100,000 people in October to around 100 today.
However, after Tier 2 status was confirmed again today, local leaders and health bosses have pointed to a recent rise in infection levels across the region and warned people to take extra care to avoid another surge.
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The very latest numbers - which cover testing up to this Monday - show that both Liverpool and Knowsley's infection rates have now ticked over 100 cases per 100,000 once again.
On Monday alone the city of Liverpool recorded 100 cases in a single day for the first time in three weeks.
Wirral has seen a sustained recent rise in cases and its infection level of 85.2 cases per 100,000 means that for the first time since September it is no longer the least affected borough in the region.
That title goes to Sefton, which has the lowest infection rate of 78.1 cases per 100,000.
