Liverpool may carry a 2-0 advantage from the first leg, but Jurgen Klopp knows his side will need to be on song to ensure they progress past RB Leipzig.
The Reds return to the Puskas Arena on Wednesday night for their second - and 'home' - leg with the German side.
The two teams travel to Budapest in markedly different moods, with Liverpool's record of five losses in their last six Premier League games contrast by Leipzig's run of six wins in the Bundesliga.
The Merseysiders' 1-0 defeat by Fulham on Sunday was especially concerning as a number of tweaks Jurgen Klopp made backfired.
One such change saw stalwart Fabinho - who has admirably filled in at centre-back this season - drop to the bench, leaving a novice defence which was preyed on by Fulham's attackers.
Klopp certainly had the contest with Leipzig in his mind as he rotated Fabinho, as the Brazilian has suffered with numerous muscle injuries this season.
The Reds boss addressed this in his press conference on Tuesday, telling reporters: "We didn’t play him from the beginning because after a long time out - then two games in a row - we thought it makes not too much sense."
In Fabinho's absence, Liverpool looked devoid of structure, leadership and intensity against Fulham, worsening the problem they have without captain Jordan Henderson - who is sidelined until April.
Klopp confirmed Fabinho is "ready" to face Leipzig but the significant problem he faces concerns where he chooses to field the former Monaco man.
As mentioned, Liverpool's tempo and drive suffers without Fabinho and Henderson in the side, but this is also a problem when they play in defence rather than midfield.
Should Jurgen Klopp field Fabinho in defence or midfield against RB Leipzig? Have your say in the comments.
Liverpool's defensive injury crisis means that Fabinho - arguably the finest holding midfielder in the Premier League last season - has not started a match in his natural position since the 2-2 draw at Everton October.
But the Reds cannot afford another lifeless performance as they take on Leipzig; Julian Nagelsmann's are masters of aggressive pressing and would punish anything other than 100 per cent intensity.
Fabinho's re-introduction to the midfield could help combat lethargy and Klopp kept his cards close to his chest as he discussed playing him in his favoured role.
"If he will play centre-half or midfield, that decision you will see tomorrow," said Klopp, who was keen to remind his side it is only "half-time" in the last-16 tie.
"You always have a chance in the next game," he warned his players. "It's half-time, we have to play the game. I have no doubt about us. We will give it a proper fight. 95 mins to use."
Of course, fielding Fabinho in midfield means Liverpool's defence will once again be made up of January signings and back-up options.
With a place in the quarter-finals on the line, Klopp must weigh up defensive solidity and midfield intensity.
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