There were a few notable changes, with the likes of Kyle Walker-Peters, Juan Foyth, Giovani Lo Celso, Christian Eriksen and Ryan Sessegnon all getting their first starts under Mourinho.
The game did not go to plan for Spurs, with Bayern eventually running out 3-1 winners in Germany.
But the game wasn't without all bad for the Premier League side, with Ryan Sessegnon bagging his first goal for the club on his first start since joining.
And added to that, it afforded Mourinho the opportunity to rest the likes of Harry Kane and Dele Alli, who stayed back in London.
Spurs now face a Wolves side who ran out 4-0 winners against Besiktas in the Europa League on Thursday night, giving them an advantage in terms of rest and recovery.
But Nuno Espirito Santo's team will be no pushovers. They sit one point and one place above Spurs in the table, and are unbeaten in their last eight Premier League games.
Three of our reporters came up with their own line ups for Mourinho's side at Molineux, and we asked the fans to pick their own.
And there were a couple of surprise starters.
In goal, Paulo Gazzaniga keeps his place as expected. But in defence, Spurs fans want Juan Foyth to retain his place at centre-back.
They picked the Argentine along with Serge Aurier and Toby Alderweireld with Jan Vertonghen at left-back ahead of Danny Rose.
In midfield, the fans have gone for an attacking line up. Moussa Sissoko would presumably need to get a lot of defensive work done in the centre alongside Dele Alli and Son Heung-min.
Meanwhile, in attack Harry Kane is flanked by Lucas Moura and Ryan Sessegnon, who would also keep his place after impressing in the Allianz Arena.
