Jose Mourinho bemoaned Tanguy Ndombele's lack of fitness following the 1-0 loss against Southampton on Wednesday afternoon.
The midfielder was substituted after just 24 minutes as he failed to recover from a knock picked up earlier in the game.
Ndombele became Spurs' record signing in the summer after joining from Lyon, but has struggled to play regularly after a succession of knocks and strains which have kept him out.
The French star controversially missed the Boxing Day win over Brighton because he "was not in condition" to play, according to Mourinho after the victory.
However, he made his comeback against Norwich in the 2-2 draw at Carrow Road on Saturday, and produced a standout performance.
But with doubts cast over his fitness just a few short days ago and another injury setback coming so quickly, Mourinho was left bemoaning his midfielder's issues so far this season.
"He [Ndombele] is always injured," Mourinho told reporters following the defeat to Southampton.
"He is injured, he is not injured; he plays one match, the next week he is injured, he plays another match.
"We are full of hopes and this is since the beginning of the season.
"Of course it is a concern, you think you have a player, you think the player is in an evolution process, he plays very well against Norwich, you think today he is ready for it and he is not ready for it.
"I cannot say much more than that because it is a situation that comes from the beginning of the season."
