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Joe Manniello

Joe Manniello's Week 6 NFL picks

Underdogs continued their strong start to the season, going 8-4-1 against the spread (ATS) in Week 5. That increases their record to 44-30-2 for the year.

With a lot of lopsided matchups this week, this could be a week to favor the favorites. Whereas last week there was only one point spread over a touchdown, this week there are five. Four are 10-plus and three 11 or more. Not surprisingly, the three 0-5 teams _ Giants, Browns and 49ers _ are double-digit road 'dogs. Can at least one of them find a way to cover?

My most confident picks ATS this week are the Falcons, Broncos, Lions and Ravens. A couple of tricky games you should avoid: Bucs-Cardinals and Rams-Jaguars.

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