All Jet2 flights travelling towards Spain have been cancelled amid coronavirus fears.
The airline cancelled flights from Birmingham to Malaga, Leeds to Alicante, Glasgow to Alicante, East Midlands to Alicante and Manchester to Alicante.
The move comes as a response to "local measures" introduced in Spain, Jet2 said.
The airline said: "In response to local measures introduced throughout Spain to prevent the spread of COVID-19, including the closure of bars, restaurants, shops and activities including any water sports, we have taken the decision to cancel all flights to Mainland Spain, the Balearic Islands and the Canary Islands with immediate effect.
"We know these local measures will have a significant impact on our customers’ holidays, which is why we have taken this decision.
"We are contacting our customers who are currently in these destinations, and who are due to travel, to advise them of their options, so we urge customers not to call us.
"This is a fast-moving and complex situation and we are reviewing our programme as a matter of urgency, so that we can fly customers back to the UK.
"The health and safety of our customers is our number one priority, and we would like to thank our customers for their understanding."
Passengers waiting in airports around the country have tweeted about their ordeal, with one writing: "Sat at the airport, waiting to hear if Jet2 planes are staying grounded or if we can go on holiday."
Another added "At departure gate for our Jet2 holiday to Fuerteventura... but looking like it's about to be cancelled."
Jet2's announcement comes as latest figures released showed the number of cases in the UK is rising.
The number of confirmed cases of coronavirus in the UK has soared to 798 - with two more people dead from the disease.
The number of those diagnosed with the virus has risen by 208 in the past 24 hours, with a total of 32,771 people having been tested.
In total 10 people have now died from the virus, that is spreading around the country and the world.
