Two Palestinians have been killed in clashes over US President Donald Trump's recognition of Jerusalem as Israel's capital, the Palestinian Health Ministry has said.
Israeli soldiers shot the two men dead on Friday near the Gaza border, a health ministry official said in a statement.
The Israeli military said hundreds of Palestinians had rolled burning tyres and thrown rocks at soldiers across the border.
"During the riots Israel Defence Forces (IDF) soldiers fired selectively towards two main instigators and hits were confirmed," the army statement said.
The Trump administration's move to recognise Jerusalem as Israeli has angered Palestinians, sparking protests across the region and wider Muslim world.
Various Palestinian groups, including militant organisation Hamas, called for a day of rage on Friday against the US and Israeli occupation.
An estimated 3,000 people marched, burned Israeli flags and stamped on posters of Mr Trump in around 30 protests across the Palestinian Territories.
In Jerusalem itself, midday prayers ended with marches through the Old City. While there was some pushing and shoving as police broke up the crowds, the protests remained largely peaceful.
Protesters chanted "Jerusalem is ours", "We don't need empty words, we need stones and Kalashnikovs" and "America is the head of the snake" as Friday prayers ended and worshippers made their way from the al Aqsa mosque to the walled Old City gates.
In Hebron, Bethlehem and Nablus, dozens of Palestinians threw stones at Israeli soldiers who fired back with tear gas.
At least 13 people were injured by live fire and 47 by rubber bullets across the West Bank and Gaza throughout the day. Dozens more suffered from tear gas inhalation, Red Crescent paramedics said.
Six arrests were made, the IDF said.
In Gaza protests were accompanied by loudspeakers blaring messages from Hamas’ leaders.
"Whoever moves his embassy to occupied Jerusalem will become an enemy of the Palestinians and a target of Palestinian factions," said leader Fathy Hammad.
"We declare an intifada until the liberation of Jerusalem and all of Palestine."
On Thursday, the militant organisation had called on the Palestinian people to rise up in a new intifada, a separate rallying cry than those for three days of Palestinian rage.
An intifada cannot be called or commanded by Palestinian leaders. While both Fatah and Hamas encouraged the two previous uprisings, the movements grew out of grassroots mass Palestinian support.
Is too early yet to tell whether protesters will take up Hamas’ call. Observers remain hopeful the relatively low levels of violence seen so far means the situation will remain calm.
Israel annexed east Jerusalem in the 1967 Six Day war, a move that was regarded as illegal by the international community. Both Israelis and Palestinians claim the holy city as their undivided capital.
Mr Trump's Wednesday announcement upended decades of existing US policy, which is currently that the status of Jerusalem will be decided at an advanced level of peace talks.
While welcomed by Israeli Prime Minister Benjamin Netanyahu, many other world leaders have expressed concern the controversial move could spark renewed violence in the region and wider Muslim world.
US Secretary of State Rex Tillerson said on Friday it would still be up to the Israelis and Palestinians to hammer out all other issues surrounding the city in future talks.
"With respect to the rest of Jerusalem, the president... did not indicate any final status for Jerusalem," he said from Paris.
"[Mr Trump] was very clear that the final status, including the borders, would be left to the two parties to negotiate and decide."
News agencies contributed to this report
