Alexis Sanchez was the star of the show on Wednesday night. The Chile international, who is on loan from Manchester United, set up Ashley Young to volley Inter ahead at San Siro after five minutes. Sanchez then dispatched a spot-kick to double the lead following a foul on Victor Moses.
Danilo D'Ambrosio got Inter’s third just before half-time.
Roberto Gagliardini headed home a Sanchez free-kick before Christian Eriksen and Antonio Candreva completed the rout.
"We brought Alexis here for his qualities," Inter coach Antonio Conte told broadcaster DAZN. "Unfortunately we lost him as an option for a long time due to injuries.
"He's now starting to find his feet and even if he's still not the Sanchez I was such a big fan of in England, what I can say is that he's on the right track. He put in a great performance."
Distance
Inter are third, eight points behind pacesetters Juventus with nine games to play.
"We kept our foot on the gas and the fact that we didn't concede is a big positive," Conte added.
Brescia, who were again without Mario Balotelli due to a contract dispute, dropped to the foot of the table. They remain eight points from safety and are winless in 14 games.
Elsewhere in Serie A, SPAL surrendered a two-goal lead and squandered two points in their fight against relegation as a 94th-minute own goal by Francesco Vicari gifted AC Milan a late equaliser in a 2-2 draw.
Flop
First-half goals from Mattia Valoti and Sergio Floccari put SPAL on top but the home side lost Marco D'Alessandro to a red card before half-time for a poor challenge on Theo Hernandez.
Zlatan Ibrahimovic returned to action for the first time since Italian football's restart after the coronavirus lockdown. He came on as a substitute for Ante Rebic in the 60th minute. But it was another substitute, Rafael Leao, who gave Milan hope with a calm finish on 79 minutes.
SPAL coach Luigi Di Biagio was sent to the stands after two yellow cards and he could only watch in despair as a lunging Vicari diverted a cross into his own net right at the death.
"It was a step backwards in terms of result because we wanted to continue the winning run," Milan coach Stefano Pioli told Sky Sport Italia.
"We weren't sharp enough in front of goal, we were too hurried and hasty in the final third."
Milan stayed seventh despite the late fightback and are two points behind Napoli, who visit fourth-placed Atalanta on Thursday, in the battle for the final Europa League berth.
