Tottenham boss Mauricio Pochettino has a decision to make at right-back, with Kyle Walker-Peters and Juan Foyth expected to miss out through injury and Serge Aurier transfer-listed.
Midfielders Eric Dier or Moussa Sissoko may be asked to deputise, although the latter will surely be needed in the middle of the park, where Tanguy Ndombele is not expected to recover from a thigh injury in time to play.
In better news, Dele Alli should be involved for the first time this season, despite missing out on the England squad, while there is pressure on Pochettino to pick Jan Vertonghen (over Davinson Sanchez) and Christian Eriksen (over Erik Lamela or Lucas Moura), despite their contract situations.
The Dane seems the more likely to get the nod, given Vertonghen is still yet to play a minute this season.
Predicted lineup
Predicted Tottenham XI [4-2-3-1]: Hugo Lloris; Serge Aurier, Toby Alderweireld, Davinson Sanchez, Danny Rose; Moussa Sissoko, Harry Winks; Heung-min Son, Christian Eriksen, Dele Alli; Harry Kane.
