Manchester United and Manchester City return to league action after bouts in the Champions League against Atalanta and Club Brugge respectively.
Cristiano Ronaldo was again the standout for Ole Gunnar Solskjaer's side in midweek as his brace was enough to salvage an important point in Bergamo, on the back of the thrashing of Spurs on Saturday.
Meanwhile in the blue half of the city, Raheem Sterling was back on the scoresheet as the Blues put four past the Belgians with Phil Foden, Riyad Mahrez and Gabriel Jesus all finding the back of the net.
They will be looking to return to winning ways in the league after suffering a 2-0 defeat last time out against Crystal Palace in a dismal performance at the Etihad Stadium.
What TV channel is Man United vs Man City on?
The match will be broadcast live in the UK on Sky Sports Main Event and Premier League with coverage starting as early as 11:30am in the build-up to the clash.
If you're not a Sky Sports subscriber, click here to upgrade or check out the latest packages.
Sky Sports Main Event is available on Sky TV channel 401 and Virgin Media channel 501. The latest Virgin Media sports package deals can be found here.
If you want to see the goals, highlights will be provided across the board later on in the afternoon and on Match of the Day from 10:30pm on BBC One.
You can also follow our matchday blog for regular match updates, analysis and reaction.
As always, your dedicated team from the Manchester Evening News will provide a rundown of the action and pick up on those insightful bits that TV cameras might have missed anyway.
What is the early Man Utd vs Man City team news?
Among the delight of Ronaldo's stunning equaliser in Italy saw the blow to United confirmed as it was announced Raphael Varane would miss up to a month of action after suffering a hamstring injury.
He was forced off midway through the first half as the 3-4-1-2 system had to be scrapped as Mason Greenwood was introduced.
Victor Lindelof also picked up a knock in the build-up to the match against Gian Piero Gasperini's side so he will face a race against time to be fit for the visit of the Premier League champions.
Paul Pogba will also be serving the last of his three-match ban for his straight red card in the defeat to Liverpool.
Ferran Torres remains the only noticeable absentee for Pep Guardiola's side as they look to apply pressure to the leading pack after the blip against Patrick Vieira's side.
Aymeric Laporte will serve a one-match suspension and miss the trip to Old Trafford after being sent-off against Palace.
Liam Delap and Torres are the long-term absentees for Pep Guardiola who will also be with Spanish central defender, Laporte but will take some confidence from Joao Cancelo's hat-trick of assists.
United (possible, 4-2-3-1): De Gea; Wan-Bissaka, Bailly, Maguire, Shaw; Fred, McTominay; Greenwood, Fernandes, Rashford; Ronaldo.
City (possible, 4-3-3): Ederson, Walker, Dias, Stones, Cancelo; De Bruyne, Rodri, Silva, Mahrez, Foden, Jesus.
