While Pep Guardiola’s side remain heavy favourites for the game at Kenilworth Road, few would doubt they are struggling at the moment.
Wednesday’s defeat at Aston Villa made it four games without a win for the champions and Guardiola admits he must find a solution.
The Hatters, meanwhile, have impressed at home. Having drawn with Liverpool and taken Arsenal to the brink, they are far from pushovers.
Here’s everything you need to know about where to watch the game.
Where to watch Luton vs Man City
TV channel: The game will be broadcast on Sky Sports Main Event, Sky Sports Premier League and Sky Sports Ultra HDR. Coverage starts at 1pm GMT ahead of the 2pm kick-off time.
Live stream: Subscribers will be able to watch on a live stream via the Sky Go website or app.