Manchester United were unable to repeat the heroics from their win against Paris Saint-Germain as they travelled to Barcelona on Tuesday night.
United were 1-0 down from the first leg and soon saw the tie slipping away as Lionel Messi fired home after 16 minutes.
Things went from bad to worse for Ole Gunnar Solskjaer's side as David De Gea allowed Messi's shot to slip under his body to make it 2-0 at half-time.
Philippe Coutinho's fantastic strike ensured Barca booked their place in the final four.
Barcelona will now take on the winner of Porto vs Liverpool with the Anfield side 2-0 up heading into the second leg tomorrow.
In the other tie of the night Juventus were shocked by Ajax in Turin. The Dutch side had previously defeated Real Madrid in the last round and they dumped out Juve with a 2-1 away victory to reach the semis.
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They will play the winners of the game between Man City and Spurs tomorrow. City go into the match looking to turn around a 1-0 loss in the first leg at the Tottenham Hotspur Stadium.
The latest Champions League odds have now been updated following tonight's result with Barca moving into strong favourites to lift the trophy in Madrid next month.
Barcelona have now been slashed into 7/4 favourites with Liverpool at 11/4 while Man City can be backed at 10/3 ahead of their home game against Spurs on Wednesday.
The latest Champions League odds
Barcelona 7/4
Liverpool 11/4
Man City 10/3
Ajax 6/1
Spurs 7/1
Porto 150/1
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