From next Wednesday each area in England will be placed into Tier 1, 2 or 3 restrictions.
The measures in each of the three tiers vary, with each region allocated a tier based on the severity of coronavirus rates in each area.
The new tiered system will come into force from Wednesday, December 2, when the national lockdown comes to an end.
The areas placed into Tier 3 includes Greater Manchester, which means the region is classed as 'Very High alert'.
As a result, the toughest restrictions will be imposed and are notably different from when the system was first introduced in October.
The biggest change is that hospitality will remain closed completely except for delivery and takeaway - just like during the national lockdown.
The latest announcement means that a total of 23.3 million people in England – 41.5% of the population – will be in Tier 3 of the government's Covid-19 restrictions from December 2.
When making the announcement, health secretary Matt Hancock said that the measures are necessary given the "scale of the threat" faced by the UK.
He also said the tiers will be reviewed in a fortnight and kept "regularly under review after that".
The first review will take place by December 16, a week before the government's 'Christmas bubbles' rules come into force.
But on Monday Boris Johnson warned the tier system was likely to remain in place until April.
This is the full list of areas in Tier 3:
North East
- Hartlepool
- Middlesbrough
- Stockton-on-Tees
- Redcar and Cleveland
- Darlington
- Sunderland
- South Tyneside
- Gateshead
- Newcastle upon Tyne
- North Tyneside
- County Durham
- Northumberland
North West
- Greater Manchester
- Lancashire
- Blackpool
- Blackburn with Darwen
Yorkshire and The Humber
- The Humber
- West Yorkshire
- South Yorkshire
West Midlands
- Birmingham and Black Country
- Staffordshire and Stoke-on-Trent
- Warwickshire, Coventry and Solihull
East Midlands
- Derby and Derbyshire
- Nottingham and Nottinghamshire
- Leicester and Leicestershire
- Lincolnshire
South East
- Slough (remainder of Berkshire is tier 2: High alert)
- Kent and Medway
South West
- Bristol
- South Gloucestershire
- North Somerset