Hibs could face an understrength Dundee United side when the two sides meet on December 19 because of Covid-19 issues.
The Tannadice club have announced that nine players are now in self-isolation after the club were hit with problems at the club's training ground.
United had already confirmed their entire non-playing staff was self-isolating and academy coach Thomas Courts would take charge of the team for Saturday's game against Livingston.
But now their squad has been decimated too, with United saying the nine players have been deemed close contacts to medical staff.
And they travel to Easter Road to take on Hibs just a day after they are due to be out of their isolation period on December 18.
A statement from the club said: “After further discussions with the Scottish FA and Tayside Health Board, we have been advised that our non-playing staff who have been self-isolating should continue to do so.
“Our academy head of tactical Performance Thomas Courts and other academy staff will lead the team for Saturday’s game against Livingston.
“Furthermore, nine members of our squad are now self-isolating as a precaution due to having close contact with medical staff at the HPC at St Andrews.
“We are grateful for the cooperation and guidance of the SPFL, Scottish FA and Tayside Health Board in this matter and we now focus our attention on preparing for Saturday's fixture.”