A large police team searched homes in Hillfields and Kingswood after stopping a vehicle and finding suspected cannabis.
Officers stopped a vehicle in Kingsway at about 4.45pm yesterday (Sunday, April 19).
An Avon and Somerset police spokesman said: "It was searched and a quantity of what was believed to be class B drugs discovered.
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"Two men, both aged 25, were arrested at the scene on suspicion of a drug supply offence.
"Searches of properties in the Hillfields and Kingswood areas of Bristol were carried out later that same day as part of our investigation."
A witness told Bristol Live she saw five police cars on Marshfield Road at around 9pm, carrying "loads of evidence bags" into a home.
The force spokesman confirmed the drug believed to have been found is suspected cannabis.
