Like Saracens, Harlequins are looking to avenge a defeat to Irish opposition last week, as they welcome Ulster to The Stoop on Friday night.
Kyle Sinckler captains a much-changed team, with Danny Care, Chris Robshaw and Marcus Smith rested.
Quins lost by a point to Ulster last week and lock Stephan Lewies wants to right the wrongs.
“The feeling is we lost to ourselves, our discipline let us down massively and ultimately cost us the game,” he said. “Now it’s putting all that preparation and feeling into trying to get a result this week.
“There were lots of positives from that game.”
Of playing the same opposition immediately, South African Lewies said: “It’s a weird one, a first for me, but it’s a good thing for both teams.
“They want to back it up, for us it gives us a second bite at them to go and get a result against them, on home turf, with our fans this time around.”
